Magnetic Resonance Analogies in Multidimensional Vibrational Spectroscopy

Nuclear Resonance Vibrational Spectroscopy (NRVS) of Fe–S model compounds, Fe–S proteins, and nitrogenase

We have used nuclear resonance vibrational spectroscopy (NRVS) to examine the nature of the Fe–S unit. Specifically, vibrational characteristics have been determined, and through incremental steps in model system complexity, applied to analysis of the enzyme nitrogenase. This stepwise strategy demonstrates NRVS as a viable bioinorganic tool, and will undoubtedly increase the application of sync...

Single-scan multidimensional magnetic resonance.

Spatially resolved and clinically feasible relaxation-di↵usion correlation spectroscopy in the spinal cord

Introduction: Combining and correlating multidimensional magnetic resonance (MR) contrast mechanisms, e.g., D-T2, would provide novel and complementary information about dynamic molecular processes and microscopic physical and chemical environments within tissue. To date, these multidimensional relaxation–di↵usion correlation (REDCO) experiments have been primarily relegated to applications inv...

Spatially resolved multidimensional NMR spectroscopy within a single scan.

We have recently demonstrated that the spatial encoding of internal nuclear magnetic resonance (NMR) spin interactions can be exploited to collect multidimensional NMR spectra within a single scan. Such experiments rely on an inhomogeneous spatial excitation of the spins throughout the sample, and lead to indirect-domain peaks via a constructive interference among the spatially resolved spin-pa...

Detection of Glioblastoma Multiforme Tumor in Magnetic Resonance Spectroscopy Based on Support Vector Machine

Introduction: The brain tumor is an abnormal growth of tissue in the brain, which is one of the most important challenges in neurology. Brain tumors have different types. Some brain tumors are benign and some brain tumors are cancerous and malignant. Glioblastoma Multiforme (GBM) is the most common and deadliest malignant brain tumor in adults. The average survival rate for peo...